Biochemistry (211) is a 4 hours credit with 3 lectures/week and 1hour laboratory session.
It is an intensive course and laboratory course that focuses on carbohydrates and lipids digestion,
different pathways for synthesis and degradation of carbohydrates (such as metabolism of
glucose, fructose disaccharides and polysaccharides) as well as the synthesis and degradation
of fats ( such as neutral fatty acids, cholesterol) and the synthesis of the lipoproteins ( classes
and clinical disorders), bile acids and bile salts and diseases associated with carbohydrates and
lipids metabolism.
Course objectives
This course is designed for undergraduate student to know:
1- Definition of the metabolism.
2- Investigation of carbohydrates and lipid metabolism pathways in human body.
3- To describe the difference between the anabolism and catabolism in both carbohydrates and
lipids pathways
4- To understand the sequence of enzymes, mechanism of reactions and metabolites in the
major metabolic pathways.
5- To understand how that the various pathways are integrated.
6- Describe the structural features of each of the functional groups and different cofactors.
7- Description of the diseases associated with carbohydrates and lipids metabolism disorders.
8- Understanding the basic laboratory aspects of some body fluids function working
individually and in small groups.
9- The student became an independent learner, able to continue to grow as a student of science.
A- Principal Book :
-Champe,PC, Harvey,AR and Ferrier, DR. 2008, Lippincott's Illustrated Review Biochemistry, 4rd edition, Ch.7-18. Lippincott Williams & Wilkins pub.,USA, UK.
B- Others :
- Voet, D and Voet, J (2004), Biochemistry 3rd edition. John Whiley and Sons, Inc., New York.
The students performance will be evaluated as follows:
1
|
Seminar and H.W
|
15
|
15%
|
2
|
Mid term
|
20
|
20%
|
3
|
Lab. work reports+exam
|
25
|
25%
|
4
|
Final Exam
|
40
|
40%
|
|
Total
|
100
|
100%
|
What is Due
|
Topics
|
Week
|
Homework assign.#1
|
-Introduction to Metabolism:
-Metabolic pathways, mechanisms of the reactions
General Carbohydrates Metabolism.
Metabolism of monosaccharide,
Disaccharides and polysaccharide.
|
1
|
|
Glycolysis. Biomedical importance and regulation.
Utilization and the fate of glucose in the body.
Hormonal regulation of glycolysis.
Metabolism of Hexoses other than glucose.
e.g. (Fructose, mannose and galactose).
|
2
|
Homework assign.#2
|
Uronic acid pathway.
-Citric acid cycle (TCA). Biomedical importance and regulation. The Amphibolic Nature of TCA.
Oxidative Phosphorylation, ATP synthesis and regulation.
|
3
|
|
Pentose Phosphate Pathway. Regulation and control of the pathway.
Glucose-6-Phosphate Dehydrogenase Deficiency.
Other sources for NADPH.
Exam(1)
Gluconeogenesis. Control of blood sugar.
GTT. Regulation of Gluconeogenesis.
The Cori cycle.
Glycogen metabolism. Answer exam
|
4
|
Homework assign.#3
|
Glycogen Breakdown and Synthesis.
Control of Glycogen Metabolism.
Glycogen Storage Diseases.
|
5
|
|
Introduction to Lipid (Digestion, Absorption and Transport).
|
6
|
|
Lipids metabolism in Liver and Adipose tissues.
|
7
|
Homework assign.#4
|
Fatty acid Biosynthesis.
Triacylglycerols Biosynthesis.
|
8
|
|
Exam (2)
Answer exam + Fatty acid Oxidation.
Ketone Bodies.
|
9
|
Homework assign.#5
|
Cholesterol metabolism.
Pathological variations of serum cholesterol.
Answer Exam 2
|
10
|
|
Bile acids and Pigments
|
11
|
Homework assign.#6
|
Phospholipids.
|
12
|
|
Lipoproteins classification, functions and metabolism.
Lipoproteins disorders.
|
13
|
|
Integration of metabolism of Carbohydrate and
Lipids
|
14
|
|
Revision
|
15
|
|